So just what IS restless leg affliction? I’ve always thought it was just stress manifesting itself in the middle of the night and a brief stroll around the bedroom or a good stretch 303vip and it disappears. Apparently, it’s considerably more prevalent in the You. S. and several new drugs for treatment have also been approved by the FDA. Now for a medical definition:
Restless legs affliction (RLS) is a neurological disorder seen as an unpleasant feelings in the legs and an huge urge to move when at rest so that you can relieve these feelings. RLS feelings are often described by people as burning, sneaking, taking, or like pests running inside the legs. Called paresthesias (abnormal sensations) or dysesthesias (unpleasant abnormal sensations), the feelings range in seriousness from uncomfortable to irritating to painful.
The most distinctive or unusual area of the condition is that lying down and trying to relax activates the symptoms. As a result, most people with RLS have difficulties dropping off to sleep and staying in bed. Left neglected, the condition causes tiredness and normal fatigue. Many people with RLS report that their job, personal contact, and activities of day to day living are strongly affected as a result of their tiredness. They are often unable to concentrate, have reduced memory, or fail to accomplish daily tasks.
Current treatment involves dopamine agonist treatment. One such drug is Requip, drug name ropinirole. In 2005, requip became the only drug approved by the You. S. Food and Drug Administration for treating moderate to severe RLS. The drug was initially approved in 1997 for patients with Parkinson’s disease. Requip stimulates D2 and D3 type dopamine receptors, to stimulate motor neuron shooting (activity-or signaling). The particular mechanism of action for the indication of both Parkinson’s and RLS are unknown.
The medial side effects of ropinirole are interesting to say the least. It has been reported that dopamine receptor agonists stimulate compulsive playing ( NEUROLOGY 2007; 68: 301-303). Three subjects were followed from either never gambled or 1-2 visits to a casino to visiting a casino 3-4 times a week and losing up to several hundred thousand dollars. One possible mechanism of action is the stimulation of D3 receptors, the highest concentration which can be found in the mesolimbic trails [in the brain, centers for controlling the following functions] implicated in motivation, feeling, and reward behaviors, which could lead to the development of pathologic playing.
I can understand the “reward” the main gamble–USC 2nd half football games the last a couple of years have paid rents. Just goes to show how pharmacological mind games of brain function can have drastic effects.